Long Awaited Answers

I'm not sure I had ever been more excited to go to the doctor than I was today. Hold on, I take that back. Baby 1's 1st ultrasound was the most exciting moment of my life until I found out I had miscarried. But any who, I went to the endocrinologist today and met one of the most amazing doctors I have ever had the privilege of directly dealing with. After going over my recent blood work and all of my symptoms (which includes severe facial acne, facial hair (blonde, thank GOD), oily skin, irregular cycles, high testosterone levels, and infertility) she was able to diagnose me with PCOS (Poly Cystic Ovarian Syndrome)!!!

It might sound crazy but I could not be more excited to finally have someone confirm with me that there IS something wrong with me hormonally. In June of last year I had a dermatologist tell me that my acne was due to hormones. In August I had an acupuncturist tell me many of my symptoms were hormonal (excessive sweating and body heat) I wasn't sure how to approach my RE about this so it kind of just sat in the back of my mind. I certainly wasn't as educated about the reproductive system as I am now, otherwise I would of spoken up about it.

So, rather than Metformin, which is what most women seem to be treated with, my Endo chose to put me on the brand name GLUMETZA. Unlike immediate-release metformin, GLUMETZA is released slowly and steadily over several hours. This delay in the release of the medicine may result in fewer stomach-related side effects, such as nausea, in the 1st week of taking the medication. She wants to get me up to 2000mg a day, so here is my future dosing schedule:

Week 1: 500mg 1x day
Week 2: 1000 mg 1x day
Week 3: 1500 mg 1x day
Week 4: 2000 mg 1x day

She also advised she would like me to reduce my carbohydrate intake to less than 120g daily and my protein up to 60g daily (at least). She says that will boost my weight loss since I'm currently at a standstill after losing 20lbs.
**Also, She said that my initial weight gain is what actually brought the PCOS to the surface. Since I have been off of BC since April 2010, the weight gain triggered it. And even after losing the 20lbs it won't completely go away. It has actually made it worse for some strange reason. It gets worse each and every week.

SO, my other good news involves my 2 MTHFR gene mutations, which my Endo happened to know a lot about. For those who don't know what this is......it's a blood disease that deals with blood clotting and the inability for my body to metabolize Folic acid. She explained that the Folic acid that I currently have a prescription for (1mg 2x daily) is considered synthetic Folic acid. She wrote me a prescription for NEEVO DHA. This is a prenatal that also contains L-Methlyfolate, nature’s active form of folate as found in leafy green foods. L-methylfolate is superior to synthetic folic acid. Several months ago one of the BB Blog readers commented on my post about this so it has always been in my mind. And to my surprise today my Endo mentioned this so I became pretty excited. This will be taken in place of my existing Pre-Natal 1x daily. On a side note, she did tell me that these mutations were most likely the cause of my 3 miscarriages (not the 1 tubal though). No one has yet to tell me that (not even my RE) so it was such an amazing feeling to hear that news. Nearly 2 years I have been waiting to hear that.

If you also unfortunate enough to have 2 mutuations of the MTHFR gene and would like additional information, here is the brands website:
http://www.neevodha.com/

Well, that is all I have for now, I will be very surprised if many make it through reading this entire posting. If you do, I much appreciate it :) So I end this cold rainy day with hope in my heart. Sad songs didn't sound so sad today, and my optimism is at the highest it has been in a very very long time. Please keep me in your prayers that I will soon get my baby back. I know he is up there waiting for me to bring him back down :) Let's hope the 5th time's a charm!!

Can't get pregnant, can't get unpregnant

I don’t want to spend too much time talking about the D&E itself. I will say that if you take away the heartbreak, the procedure is fairly simple and painless. We hadn’t told anyone about the pregnancy except my mom and my best friend, so we only had to break the bad news to two people. My mom had apparently told her friends, so she got to untell them as well.

My RE’s office needed to know if the defect was genetic in origin, so we had karyotyping done. Neural tube defects (NTDs) aren’t typically genetic, and ours was no exception (meaning it wasn’t the donor’s fault). I never did ask if the donor was allowed to cycle again. I did find out the sex of the baby, which I’ll refrain from sharing. (Mr. GB didn’t want to know.) I also received tiny footprints, which are tucked away safe for now.

(We don’t know what caused the defect. They say that NTDs can be prevented with folic acid. I’d been taking prenatal vitamins for years, but it wasn’t enough. At my request I was tested for MTHFR (a disorder that can cause difficulty in absorbing folic acid), and I don’t have that mutation. My homocysteine levels were also normal. I read NTDs are more common with IVF…I always wonder if the lengthy embryo transfer was the cause. I also read that hot tubs and saunas can cause NTDs, and I wonder if sunbathing was the cause, even though I sunbathed after the window for NTDs closed. It was probably just horrible bad luck. I’m taking 4 mg of folic acid now, just in case. I have a 1% chance of it happening again. I hope it doesn’t.)

As I was recovering from the D&E, I was more determined than ever to try again. In fact, I was filled with an odd sense of hope that’s really hard to explain. Maybe it was just a coping mechanism. I did have bouts of sadness and grief, but I was ready for AF to arrive and start a new donor cycle.

Except AF was nowhere to be seen, and my HPTs were still positive. And I was still bleeding, like for a month. Went back to the MFM’s office for an ultrasound but nothing looked suspicious. She gave me Cytotec/Misoprostol to try to flush out my uterus, but nothing happened. Mentioned the bleeding to my donor coordinator, who talked to my RE, who told me to come in for a hysteroscopy to look around. The camera showed that my uterus was filled with cobwebs (aka “products of conception”) and a second D&C was needed. My RE said I could get the procedure done at the RE’s surgical center, but we’d have to wait a month.

So we commenced waiting. Again. We’re talking 77 days between the first procedure and the second.

Surprise surprise, AF arrived 58 days after my D&E. I will spare you the details but let’s just say it was the worst period EVER. My RE still recommended the D&C, but the good news was that I got to go on the pill, which meant I’d finally have control of my cycle back and we were finally ready to start looking at donors again. YAY!

I had my second D&C on August 11, the same day we put down our donor deposit. In the next few days I’ll talk a bit about our selection process (my criteria changed dramatically), a slight setback, and where we are today. But for now, I’ve got to run upstairs for a Lupron shot!

To be continued…

Golden Bud